IPAMORELIN - 10MG

Ipamorelin 10mg – Research Grade Peptide

Ipamorelin 5mg is a research-grade pentapeptide known for its potent and selective stimulation of growth hormone release. As a synthetic ghrelin receptor agonist, it is utilized in scientific studies of the growth hormone secretagogue pathway, offering a unique profile with minimal off-target hormonal effects.

Product Details

• Synonyms: Ipamorelin Acetate; NNC 26-0161; Aib-His-D-2-Nal-D-Phe-Lys-NH₂
• CAS Number: 170851-70-4
• Molecular Formula: C₃₈H₄₉N₉O₅
• Molecular Weight: 711.9 g/mol
• Solubility: Soluble in aqueous solutions (requires reconstitution in water or buffer); very slight solubility in methanol or acetonitrile; moderate solubility in DMSO

Background: Ipamorelin is a pentapeptide growth hormone secretagogue that acts as a selective agonist of the ghrelin receptor (growth hormone secretagogue receptor, GHS-R1a). By mimicking ghrelin’s action at these receptors in the hypothalamus and pituitary, ipamorelin triggers pulsatile secretion of GH, leading to downstream increases in IGF-1. It was designed to maximize GH release while minimizing off-target hormonal effects. Notably, ipamorelin displays high specificity for GH release: in preclinical studies it robustly stimulated GH but, unlike earlier secretagogues (e.g. GHRP-6 or GHRP-2), it did not significantly elevate levels of ACTH or cortisol even at doses hundreds of times above the GH-effective dose. This selectivity suggests a lower risk of side effects related to stress hormones, making ipamorelin a promising candidate for clinical development in growth disorders or catabolic states.

References:
[1] https://pubmed.ncbi.nlm.nih.gov/9849822/

For Research Use Only.

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