KPV
KPV
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KPV – Research Grade Peptide
KPV 10mg is a research-grade tripeptide commonly utilized in scientific studies of inflammatory regulation, epithelial barrier integrity, and melanocortin signaling. Supplied as a lyophilized powder for laboratory research, KPV corresponds to the C-terminal tripeptide fragment of α-melanocyte-stimulating hormone (α-MSH 11-13) and is investigated for targeted anti-inflammatory effects across skin, gastrointestinal, and mucosal research models.
Product Details
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Synonyms: KPV; Lys-Pro-Val; α-MSH (11-13); alpha-melanocyte-stimulating hormone fragment 11-13
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CAS Number: 67727-97-3
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Molecular Formula: C₁₆H₃₀N₄O₄ (free peptide; supplier form may vary)
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Molecular Weight: 342.43 g/mol (free peptide; supplier form may vary)
- Solubility: Soluble in water and aqueous buffers following reconstitution; limited solubility in most organic solvents
Background: KPV is a short melanocortin-derived tripeptide representing the minimal C-terminal pharmacophore associated with much of α-MSH’s anti-inflammatory activity. In published research, KPV and closely related α-MSH-derived tripeptides have been shown to modulate inflammatory signaling, including downregulation of NF-κB-associated pathways and reductions in pro-inflammatory cytokine output in experimental systems.[1,2] In intestinal research, KPV has been investigated for localized anti-inflammatory activity and epithelial support in models of colitis and barrier dysfunction. In dermatologic research, melanocortin-derived tripeptides have demonstrated anti-inflammatory effects in irritant and allergic inflammatory skin models, and the review literature describes limited early human/translational skin data supporting topical anti-inflammatory activity.[1] Because the isolated KPV literature remains more preclinical and translational than large-scale clinical, KPV is best characterized as a promising laboratory research tool for studies related to dermatitis, inflammatory bowel disease, wound microenvironments, mucosal repair, and immune-mediated epithelial injury.
References:
[1] Brzoska T, Luger TA, Maaser C, Abels C, Böhm M. Alpha-Melanocyte-Stimulating Hormone and Related Tripeptides: Biochemistry, Anti-inflammatory and Protective Effects in Vitro and in Vivo, and Future Perspectives for the Treatment of Immune-Mediated Inflammatory Diseases. Endocr Rev. 2008;29(5):581-602. doi:10.1210/er.2007-0027
[2] Catania A, Gatti S, Colombo G, Lipton JM. Targeting melanocortin receptors as a novel strategy to control inflammation. Pharmacol Rev. 2004;56(1):1-29. doi:10.1124/pr.56.1.1
For Research Use Only. This product is provided strictly for laboratory experimentation and is not for human or veterinary use.
What is the purity of your peptides?
What is the purity of your peptides?
Our peptides are high-purity, research-grade products. In fact, the vast majority of our peptides have a purity level of 99% or higher (as determined by analytical testing). We ensure this by putting each batch through rigorous purification processes and quality tests. Every batch is analyzed using advanced techniques like HPLC (to measure purity) and Mass Spectrometry (to confirm molecular weight and identity).
We also have independent third-party labs verify the purity to provide an extra layer of confidence. A detailed Certificate of Analysis is maintained for each batch, so you can review the exact purity percentage and test results for your specific vial if needed.
With Stratford Peptides, you can trust that you’re getting some of the purest peptides available on the market, which is crucial for reliable research outcomes.
How are your peptides stored and shipped?
How are your peptides stored and shipped?
All our peptides are supplied as lyophilized (freeze-dried) powders, which are very stable for shipping.
We store them in optimal conditions (frozen storage) at our facility, and when we ship them to you, they are sealed in airtight vials.
Shipping: We pack orders carefully to ensure the peptides remain stable during transit. Lyophilized peptides can handle normal shipping times without issue – short exposures to ambient temperatures (a few days in shipping) do not significantly affect product integrity. For most orders, we use padded mailers or insulated packaging to protect the vials. If you order a product that is particularly temperature-sensitive, we will include appropriate cooling packs or dry ice in the package as needed. Our goal is to make sure the peptides arrive in perfect condition. Once delivered, you should place the peptides in a freezer for long-term storage (Refrigerate if you plan to use them immediately).
For more guidance on how to handle and store your peptides upon arrival, please refer to our blog or the instructions included with your order.
Do you provide Certificates of Analysis (COA)?
Do you provide Certificates of Analysis (COA)?
Yes, we provide Certificates of Analysis for our peptide products. A Certificate of Analysis is a document from our quality control lab (or an independent lab) that verifies the identity, purity, and quality of the peptide batch. It includes the results of analytical tests – for example, the HPLC purity percentage, mass spectrometry verification of the molecular weight, and other relevant data.
We maintain a COA for every batch we produce, to ensure transparency and quality assurance. If you would like the COA for a product you purchased, simply contact us or check the product page (in some cases we make them downloadable). The COA lets you see that, say, your peptide is >99% pure and matches the expected formula. This is part of our commitment to providing research, trusted peptides, you don’t have to just take our word for it; the lab results speak for themselves.
Are your peptides synthetic or naturally derived?
Are your peptides synthetic or naturally derived?
All of our peptides are synthetic, meaning they are created by chemical synthesis in a lab. We do not use peptides extracted from animal or human tissues. The synthetic route allows us to produce peptides with precise control over their sequence and purity. In modern peptide science, chemical synthesis is the preferred method for research peptides because it’s efficient and yields highly pure products. By synthesising peptides, we can also incorporate special modifications or create analogues that might not be readily found in nature, which is valuable for research.
In summary, when you purchase from Stratford Peptides, you are getting lab-synthesised peptides that are tailor-made for consistency and quality. This ensures that each batch is reproducible and free from contaminants that could be present in peptides derived from natural sources.
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